La membrana alveolo-capilar

Carmelo Dueñas Castell, MD., Adriana Fortich Salvador, MD., Guillermo Ortiz Ruiz, MD.

Resumen


La membrana alveolo-capilar ha sido motivo de múltiples estudios y recientemente se ha avanzado mucho en su papel vital en el intercambio gaseoso y en la modulación inmune ante diversas situaciones clínicas. A continuación se revisan los aspectos más destacados del conocimiento científico actual sobre la membrana alveolo-capilar y su rol en condiciones como el síndrome de dificultad respiratoria aguda y la lesión pulmonar asociada a ventilación mecánica. Se resume, además, la evidencia existente sobre el papel de diversas células y mediadores humorales en la fisiopatología de la membrana alveolo-capilar. Comprender la literatura existente sobre el papel inmunomodulador de la membrana alveolo-capilar y su interacción con células, productos inmunes, receptores, canales y vías de expresión debe facilitar el conocimiento sobre los aspectos fisiopatológicos de dicha membrana y esto a su vez debería redundar en un mejor manejo de los pacientes críticos e impactar en desenlaces clínicos vitales.


Palabras clave


membrana alveolo-capilar; síndrome de dificultad respiratoria aguda; lesión pulmonar asociada a ventilador

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Referencias


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DOI: http://dx.doi.org/10.30789/rcneumologia.v26.n3.2014.38

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