Biological, pathobiological and bioclinical bases of pulmonary surfactant metabolism in the human species

Bases biológicas, patobiológicas y bioclínicas del metabolismo del surfactante pulmonar en la especie humana

Published 2008-09-01

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Biological, pathobiological and bioclinical bases of pulmonary surfactant metabolism in the human species.
rev. colomb. neumol. [Internet]. 2008 Sep. 1 [cited 2024 Nov. 22];20(3):92-106.
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Grégory Alfonso García
Docente Experto en Genética, Bioquímica, y Biología Celular y Molecular Humana
    Paulina Ojeda
    Patólogo. Hospital Santa Clara
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      The surfactant metabolism dysfunction pulmonary(SMDP), classically termed as Pulmonary Alveolar Proteinosis(PAP) are a unusual respiratory disorder characterized by abundant and excessive accumulation of surfactant-derived phospholipids and protein components in the pulmonary alveoli and distal airways, with disturbances associated secondary of pulmonary gas exchange and engendering respiratory insufficiency. At least three general pathophysiologic mechanisms may lead to the characteristic feature of PAP: Primary (idiopathic, essential, acquired or adult), secondary and congenital.

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