Review of topic on the Diagnosis of Venous Thrombosis and Pulmonary Embolism in Patients with Neoplasms. Role of fibrin Fragment D

Revisión de los métodos diagnósticos de la Trombosis Venosa Profunda y Embolismo Pulmonar. Rol del Fragmento D de fibrina

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Vol. 36 No. 2 (2024): junio-diciembre
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Garay-Fernández M, Arias Mira DE. Review of topic on the Diagnosis of Venous Thrombosis and Pulmonary Embolism in Patients with Neoplasms. Role of fibrin Fragment D.
rev. colomb. neumol. [Internet]. 2024 Nov. 26 [cited 2025 Jun. 13];36(2):41-50. Disponible en: https://doi.org/10.30789/rcneumologia.v36.n2.2024.728
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Manuel Garay-Fernández
Universidad El Bosque image/svg+xml
    https://orcid.org/0000-0002-3249-6501
    David Esteban Arias Mira
    Universidad El Bosque image/svg+xml
      https://orcid.org/0000-0001-7263-5572
      Show authors biography

      Manuel Garay-Fernández,

      Médico Internista Intensivista Neumólogo. Universidad El Bosque, Hospital Santa Clara. Bogotá, Colombia. ORCID: https://orcid.org/0000-0002-3249-6501

      David Esteban Arias Mira,

      Médico Residente de Medicina Interna. Universidad El Bosque, Hospital Santa Clara. Bogotá, Colombia. 

      Introduction. Venous thromboembolic disease, represented by deep venous thrombosis and pulmonary embolism, constitutes a highly prevalent pathology in both in- and out-of-hospital patients, with an increasing number of associated risk factors, some of them not represented in the risk and prognosis scales currently implemented, such as solid organ neoplastic and hematological pathologies, which have been associated with false positives in the results of tests such as D-dimer and recurrent thrombotic events, which makes it difficult to establish a diagnostic algorithm and anticoagulation time after resolution of the initial thrombotic event. 

      Objective. To document the use of compression Doppler ultrasound of the lower limbs, Pulmonary Resonance Angiography (PRA), and Chest Computed Tomography with Iodine Mapping (CTIM) in patients with cancer and suspected thrombotic events have a negative predictive value comparable to D-dimer in the absence of cancer. Therefore, more significant implementation of these diagnostic strategies in the algorithms for these patients is required.

      Materials and methods. A search of published literature in the Medline (PubMed), OncoWeb, and CancerLit (HealthGate) databases, with the following MeSH terms: pulmonary embolism, venous thrombosis, neoplasms, diagnosis, D-dimer or fibrin fragment D, and epidemiology (epidemiology). 

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