Review of topic on the Diagnosis of Venous Thrombosis and Pulmonary Embolism in Patients with Neoplasms. Role of fibrin Fragment D

Revisión de los métodos diagnósticos de la Trombosis Venosa Profunda y Embolismo Pulmonar. Rol del Fragmento D de fibrina

Published 2024-07-16

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Review of topic on the Diagnosis of Venous Thrombosis and Pulmonary Embolism in Patients with Neoplasms. Role of fibrin Fragment D.
rev. colomb. neumol. [Internet]. 2024 Jul. 16 [cited 2024 Nov. 21];. Disponible en: https://doi.org/10.30789/rcneumologia.v36.n2.2024.728
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Manuel Garay-Fernández
Universidad El Bosque image/svg+xml
    https://orcid.org/0000-0002-3249-6501
    David Esteban Arias Mira
    Universidad El Bosque image/svg+xml
      https://orcid.org/0000-0001-7263-5572
      Show authors biography

      Manuel Garay-Fernández,

      Médico Internista Intensivista Neumólogo. Universidad El Bosque, Hospital Santa Clara. Bogotá, Colombia. ORCID: https://orcid.org/0000-0002-3249-6501

      David Esteban Arias Mira,

      Médico Residente de Medicina Interna. Universidad El Bosque, Hospital Santa Clara. Bogotá, Colombia. 

      Venous thrombus embolic disease, represented by Venous Thrombosis and Pulmonary Embolism, constitutes a pathology of high prevalence both in intra and extra hospital patients, with an increasing number of associated risk factors, some of them not represented in the currently implemented risk and prognosis scales, such as solid organ and hematological neoplastic pathologies, which have been associated with false positives in the results of tests such as D-dimer and recurrent thrombotic events, which makes it difficult to establish an algorithm for diagnosis and anticoagulation time after resolution of the initial thrombotic event. In our review, it was documented that the use of lower limb compression Doppler ultrasound, PRA and ATMY in patients with cancer and suspected thrombotic events have a negative predictive value comparable to D-dimer in the absence of cancer, therefore, it is requires greater implementation of these diagnostic strategies in the algorithms of these patients.

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      1. Patel P, Patel P, Bhatt M, Braun C, Begum H, Nieuwlaat R, et al. Systematic review and meta-analysis of outcomes in patients with suspected deep vein thrombosis. Blood Advances. 2020; 4(12): 2779 – 2788. doi:10.1182/bloodadvances.2020001558
      2. Germini F, Zarabi S, Eventov M, Turcotte M, Li M, de Wit K. Pulmonary embolism prevalence among emergency department cohorts: A systematic review and meta-analysis by country of study J Thromb Haemost. 2021; 19: 173–185. doi: 10.1111/jth.15124
      3. Klemen N, Feingold P, Hashimoto B, Wang M, Kleyman S, Brackett A, et al. Mortality risk associated with venous thromboembolism: a systematic review and Bayesian meta-analysis. The Lancet Haematology. 2020; 7: 583-593. doi: 10.1016/S2352-3026(20)30211-8
      4. Gao Y, Wang Y, Cao X, Wang X, Zheng Q, Zhao H, et al. Rapid prediction of deterioration risk among non-high-risk patients with acute pulmonary embolism at admission: An imaging tool. International Journal of Cardiology 338. 2021 229–236. doi: 10.1016/j.ijcard.2021.06.013
      5. Rahmani J, Roudsari A, Bawadi H, et al, Relationship between body mass index, risk of venous thromboembolism and pulmonary embolism: A systematic review and dose-response meta-analysis of cohort studies among four million participants. Thrombosis Research. 2020. doi: 10.1016/j.thromres.2020.05.014
      6. Jara-Palomares L, van Es N, Praena-Fernandez J, Le Gal G, Otten H, Robin P, et al. Relationship between type of unprovoked venous thromboembolism and cancer location: An individual patient data meta-analysis. Thrombosis Research. 2019; 176: 79–84. doi: 10.1016/j.thromres.2019.02.011
      7. Meyer H, Wienke A, Surov A. Incidental pulmonary embolism in oncologic patients—a systematic review and meta-analysis. Support Care Cancer. 2021; 29: 1293–1302. doi: 10.1007/s00520-020-05601-y
      8. Giustozzi M, Connors J, Ruperez A, Szmit S, Falvo N, Cohen A, et al. Clinical characteristics and outcomes of incidental venous thromboembolism in cancer patients: Insights from the Caravaggio study. J Thromb Haemost. 2021;19:2751–2759. doi: 10.1111/jth.15461
      9. Mulder F, Di Nisio M, 3, Ay C, Carrier M, Bosch F, Segers S, et al. Clinical implications of incidental venous thromboembolism in cancer patients. Eur Respir J 2020; 55: 1901697. doi: 10.1183/13993003.01697-2019
      10. Nisio D, Candeloro M, Rutjes A, Porreca E. Venous thromboembolism in cancer patients receiving neoadjuvant chemotherapy: a systematic review and meta-analysis. Journal of Thrombosis and Haemostasis. 2018; 16: 1336–1346. doi: 10.1111/jth.14149
      11. Robertson L, Yeoh SE, Broderick C, Stansby G, Agarwal R. Effect of testing for cancer on cancer- or venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE. Cochrane Database of Systematic Reviews. 2018; 11 (CD010837). doi: 10.1002/14651858.CD010837.pub4
      12. Bao Y, Gao B, Yan P, Tian L, Yang K. The effectiveness and safety of thromboprophylaxis in cancer patients based on Khorana score: a meta analysis and systematic review of randomized controlled trials. Clinical and Translational Oncology. 2020; 22(11):1992-2001. doi: 10.1007/s12094-020-02336-4
      13. Galanaud J-P, Blaise S, Sevestre MA, Terrisse H, Pernod G, Gaillard C, et al. Long-term outcomes of isolated superficial vein thrombosis in patients with active cancer. Thrombosis Research. 2018; 171:179-186. doi: 10.1016/j.thromres.2018.04.013
      14. Chopard R, Ehlers I, Piazza G. Diagnosis and Treatment of Lower Extremity Venous Thromboembolism - A Review. JAMA. 2020;324(17):1765-1776. doi: 10.1001/jama.2020.17272
      15. Ntinopoulou P, Ntinopoulou E, Papathanasiou I.V, Fradelos E.C, Kotsiou O, Roussas N, et al. Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review. Medicina. 2022, 58: 1290-1304 doi: 10.3390/medicina58091290
      16. Hayssen H, Cires-Drouet R, Englum B, Nguyen P, Sahoo S, Mayorga-Carlin M, et al. Systematic review of venous thromboembolism risk categories derived from Caprini score. J Vasc Surg Venous Lymphat Disord 2022;10:1401-1409. doi: 10.1016/j.jvsv.2022.05.003
      17. Bhatt M, Braun C, Patel P, Patel P, Begum H, Wiercioch W, et al. Diagnosis of deep vein thrombosis of the lower extremity: a systematic review and meta-analysis of test accuracy. Blood advances. 2020; 4(7): 1250-1264. doi: 10.1182/bloodadvances.2019000960
      18. Patel P, Braun C, Patel P, Bhatt M, Begum H, Wiercioch W, et al. Diagnosis of deep vein thrombosis of the upper extremity: a systematic review and meta-analysis of test accuracy. Blood advances. 2020; 4(11): 2516-2522. doi: 10.1182/bloodadvances.2019001409
      19. Takada T, Van Doorn S, Parpia S, de Wit K, Anderson D, Stevens S. Diagnosing deep vein thrombosis in cancer patients with suspected symptoms: An individual participant data meta-analysis. J Thromb Haemost. 2020; 18: 2245–2252. doi: 10.1111/jth.14900
      20. Robertson L, Broderick C, Yeoh SE, Stansby G. Effect of testing for cancer on cancer- or venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE. Cochrane Database of Systematic Reviews. 2021, 10 (CD010837). doi: 10.1002/14651858.CD010837.pub4
      21. Ordieres-Ortega L, Demelo-Rodríguez P, Galeano-Valle F, et al. Predictive value of D-dimer testing for the diagnosis of venous thrombosis in unusual locations: A systematic review. Thromb Res. 202; 189: 5-12. doi: 10.1016/j.thromres.2020.02.009
      22. Aguilara C, Sarborib M, D’Angeloc A, Kabrheld C, Grocee J, de Maistref E, et al. Validation of the STA-Liatest DDi assay for exclusion of proximal deep vein thrombosis according to the latest Clinical and Laboratory Standards Institute/Food and Drug Administration guideline: results of a multicenter management study. Blood Coagul Fibrinolysis. 2018; 29: 562–566. doi: 10.1097/MBC.0000000000000750
      23. Kraaijpoel N, Carrier M, Le Gal G, McInnes MDF, Salameh J-P, McGrath TA, et al. Diagnostic accuracy of three ultrasonography strategies for deep vein thrombosis of the lower extremity: A systematic review and meta-analysis. PLoS ONE. 2020; 15(2): e0228788. doi: 10.1371/journal.pone.0228788
      24. Lee JH, Lee SH, Yun SJ. Comparison of 2-point and 3-point point-of-care ultrasound techniques for deep vein thrombosis at the emergency department. A meta-analysis. Medicine. 2019; 98(22): 1-11. doi: 10.1097/MD.0000000000015791
      25. Tini G, Moriconi A, Ministrini S, Zullo V, Venanzi E, Mondovecchio G, et al. Ultrasound screening for asymptomatic deep vein thrombosis in critically ill patients: a pilot trial. Internal and Emergency Medicine. 2022; 17: 2269–2277. doi: 10.1007/s11739-022-03085-8
      26. Zhang Y, Xia H, Wang Y, Chen L, Li S, Hussein IA, et al. The rate of missed diagnosis of lower-limb DVT by ultrasound amounts to 50% or so in patients without symptoms of DVT. Medicine. 2019; 98 (37): e17103. doi: 10.1097/MD.0000000000017103
      27. Van Dam L,1, Dronkers C, Gautam G, Eckerbom A, Ghanima W, Gleditsch J, et al. Magnetic resonance imaging for diagnosis of recurrent ipsilateral deep vein thrombosis. Blood. 2020; 135(16):1377-1385. doi: 10.1182/blood.2019004114
      28. Zhang Y, Begum H, Grewal H, Etxeandia-Ikobaltzeta I, Morgano G, Khatib R, et al. Cost-effectiveness of diagnostic strategies for venous thromboembolism: a systematic review. Blood advances. 2022; 6 (2): 544-567. doi: 10.1182/bloodadvances.2020003576
      29. Barco S, Ende-Verhaar Y, Becattini C, Jimenez D, Lankeit M, Huisman M, et al. Differential impact of syncope on the prognosis of patients with acute pulmonary embolism: a systematic review and meta-analysis. European Heart Journal. 2018; 39: 4186–4195. doi: 10.1093/eurheartj/ehy631
      30. Maanen R, Trinks-Roerdink E, Rutten F, Geersing G. A systematic review and meta-analysis of diagnostic delay in pulmonary embolism. European Journal Of General Practice. 2022; 28(1): 165–172. doi: 10.1080/13814788.2022.2086232
      31. Zuin M, Rigatelli G, Zuliani G, Adami A, Zonzin P, Roncon L. Seizures as the first clinical manifestation of acute pulmonary embolism: an underestimate issue in neurocritical care. Neurol Sci. 2020; 41(6): 1427-1436. doi: 10.1007/s10072-020-04275-y
      32. Jiménez D, Agustí A, Tabernero E, Jara-Palomares L, Hernando A, Ruiz-Artacho P, et al. Effect of a Pulmonary Embolism Diagnostic Strategy on Clinical Outcomes in Patients Hospitalized for COPD Exacerbation. A Randomized Clinical Trial. JAMA. 2021; 326 (13): 1277-1285. doi: 10.1001/jama.2021.14846
      33. Lahera A, Richardsb G. Cardiac arrest due to pulmonary embolism. Indian Heart Journal 70. 2018: 731–735. doi: 10.1016/j.ihj.2018.01.014
      34. Stalls M, Takada T, Kraaijpoel N, Es N, Büller H, Courtney M, et al. Safety and Efficiency of Diagnostic Strategies for Ruling Out Pulmonary Embolism in Clinically Relevant Patient Subgroups. A Systematic Review and Individual-Patient Data Meta-analysis. Ann Intern Med. 2022; 175: 244-255. doi: 10.7326/M21-2625
      35. Geersing G, Takada T, Klok F, Bu ̈lle R, Courtney M, Freund Y, et al. Ruling out pulmonary embolism across different healthcare settings: A systematic review and individual patient data meta-analysis. 2022. PLoS Med; 19 (1): e1003905. doi: 10.1371/journal.pmed.1003905
      36. Patel P, Patel P, Bhatt M, Braun C, Begum H, Wiercioch W, et al. Systematic review and meta-analysis of test accuracy for the diagnosis of suspected pulmonary embolism. Blood advances. 2020; 4 (18): 4296-4311. doi: 10.1182/bloodadvances.2019001052
      37. Wang Y, Feng Y, Du R, Yang X, Huang J, Mao H. Prognostic Performance of Hestia Criteria in Acute Pulmonary Embolism: A Systematic Review and Meta-Analysis. Clinical and Applied Thrombosis/Hemostasis. 2022; 28: 1-11. doi: 10.1177/10760296221126173
      38. El-Menyara A, Sathiana B, Al-Thanic H. Elevated serum cardiac troponin and mortality in acute pulmonary embolism: Systematic review and meta-analysis. Respiratory Medicine. 2019; 157: 26–35. doi: 10.1016/j.rmed.2019.08.011
      39. Zuin M, Rigatelli G, Turchetta S, Zonzin P, Zuliani G, Roncon L. Left atrial size measured on CT pulmonary angiography: another parameter of pulmonary embolism severity? A systematic review. Journal of Thrombosis and Thrombolysis. 2020; 50 (1): 181-189. doi: 10.1007/s11239-019-01994-8
      40. Chornenki N, Poorzargar K, Shanjer M, Mbuagbaw L, Delluc A, Crowther M, et al. Detection of right ventricular dysfunction in acute pulmonary embolism by computed tomography or echocardiography: A systematic review and meta-analysis. J Thromb Haemost. 2021; 19: 2504–2513. doi: 10.1111/jth.15453
      41. Kagima J, Stolbrink M, Masheti S, Mbaiyani C, Munubi A, Joekes E, et al. Diagnostic accuracy of combined thoracic and cardiac sonography for the diagnosis of pulmonary embolism: A systematic review and meta-analysis. PLoS ONE 15(9): e0235940. doi: 10.1371/journal.pone.0235940
      42. Chen W, Xu K, Li Y, Hao M, Yang Y, Liu X, et al. Clinical value of thoracic ultrasonography in the diagnosis of pulmonary embolism: a systematic review and meta-analysis. Med Ultrason. 2022; 24 (2): 226-234. doi: 10.11152/mu-3049
      43. Ransome W, Dizonb J, Guerreroa K, Chauc M. Diagnostic test accuracy of imaging modalities for adults with acute pulmonary embolism: A systematic review and meta-analysis. Journal of Medical Imaging and Radiation Sciences. 2023; 54 (1): 178–194. doi: 10.1016/j.jmir.2022.11.003
      44. Andruchow J, Grigat D, McRae A, Innes G, Vatanpour S, Wang D, et al. Decision support for computed tomography in the emergency department: a multicenter cluster‐randomized controlled trial. Canadian Journal of Emergency Medicine. 2021; 23: 631–640. doi: 10.1007/s43678-021-00170-3
      45. Dissaux B, Le Floch P, Robin P, Bourhis D, Couturaud F, Salaun P, et al. Pulmonary perfusion by iodine subtraction maps CT angiography in acute pulmonary embolism: comparison with pulmonary perfusion SPECT (PASEP trial). Eur Radiol. 2020; 30(9): 4857-4864. doi: 10.1007/s00330-020-06836-3
      46. Sosa D, Lehr A, Zhao H, Roth S, Lakhther V, Bashir R, et al. Impact of pulmonary embolism response teams on acute pulmonary embolism: a systematic review and meta-analysis. Eur Respir Rev 2022; 31: 220023. doi: 10.1183/16000617.0023-2022
      47. Hua X, Han S-H, Wei S-Z, Wu Y, Sha J, ZhuX-L. Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis. PLoS ONE. 2019; 14(9): e0223230. doi: 10.1371/journal.pone.0223230
      48. Lu Y, Zhang L, Zhang O, Zhang Y, Chen D, Lou J, Jiang J, Ren C. The association of D-dimer with clinicopathological features of breast cancer and its usefulness in differential diagnosis: A systematic review and meta-analysis. PLoS ONE. 2019; 14(9): e0221374. doi: 10.1371/journal.pone.0221374
      49. Lin Y, Liu Z, Qiu Y, Zhang J, Wu H, Liang R. Clinical significance of plasma D-dimer and fibrinogen in digestive cancer: A systematic review and meta-analysis. European Journal of Surgical Oncology. 2018; 44: 1494-1503. doi: 10.1016/j.ejso.2018.07.052
      50. Iwuji K, Almekdash H, Nugent K, Islam E, Hyde B, Kopel J, et al. Age-Adjusted D-Dimer in the Prediction of Pulmonary Embolism: Systematic Review and Meta-analysis. Journal of Primary Care & Community Health. 2021;12 (1): 1–8. doi: 10.1177/21501327211054996
      51. Parpia S, Lapner S, Schutgen R, Elf J, Geersing G, Kearon C. Clinical pre-test probability adjusted versus age-adjusted D-dimer interpretation strategy for DVT diagnosis: A diagnostic individual patient data meta-analysis. J Thromb Haemost. 2020; 18: 669–675. doi: 10.1177/21501327211054996
      52. Yang M, Qi J, Tang Y, Wu D, Han Y. Increased D-dimer predicts the risk of cancer-associated recurrent venous thromboembolism and venous thromboembolism: A systematic review and meta-analysis. Thromb Res. 2020; 196: 410-413. doi: 10.1016/j.thromres.2020.09.031
      53. Kumar V, Shaw J, Key N, Ilich A, Mallick R, Wells P, et al. D-Dimer Enhances Risk-Targeted Thromboprophylaxis in Ambulatory Patients with Cancer. The Oncologist. 2020; 25:1075–1083. doi: 10.1002/onco.13540
      54. Deng H-Y, Ma X-S, Zhou J, Wang R-L, Jiang R, Qiu X-M. High pretreatment D-dimer level is an independent unfavorable prognostic factor of small cell lung cancer. A systematic review and meta-analysis. Medicine. 2021; 100:15-22. doi: 10.1097/MD.0000000000025447
      55. Ma M, Cao R, Wang W, Wang B, Yang Y, Huang Y, et al. The D‑dimer level predicts the prognosis in patients with lung cancer: a systematic review and meta‑analysis. J Cardiothorac Surg. 2021; 16:243-254. doi: 10.1186/s13019-021-01618-4
      56. Zhang C, Jia Y, Jia Y, Zhang X, Li K. Prognostic and predictive value of plasma d-dimer levels in patients with small-cell lung cancer. Int J Clin Oncol. 2018; 23 (6): 1070-1075. doi: 10.1007/s10147-018-1320-5
      57. Ilich A, Kumar V, Henderson M, Mallick R, Wells P, Carrier M, et al. Biomarkers in cancer patients at risk for venous thromboembolism: data from the AVERT study. Thromb Res. 2020; 191: Suppl 1:S31-S36. doi: 10.1016/S0049-3848(20)30394-7
      58. Memon A, Sundquist K, PirouziFard M, Elf J, Strandberg K, Svensson P, et al. Identification of novel diagnostic biomarkers for deep venous thrombosis. Br J Haematol. 2018; 181 (3): 378-385. doi: 10.1111/bjh.15206

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