Primary adenocarcinoma of the lung with signet-ring cells and ALK rearrangement. Two case reports.

Adenocarcinoma primario de pulmón con células en anillo de sello y reordenamiento de ALK. Reporte de dos casos

Published 2022-11-30

Open | Download
PDF (Spanish) FLIP
Issue
Vol. 34 No. 2 (2022)
Section
Reporte de caso
How to Cite
Primary adenocarcinoma of the lung with signet-ring cells and ALK rearrangement. Two case reports.
rev. colomb. neumol. [Internet]. 2022 Nov. 30 [cited 2024 Dec. 4];34(2):80-5. Disponible en: https://doi.org/10.30789/rcneumologia.v34.n2.2022.585
DOI

https://doi.org/10.30789/rcneumologia.v34.n2.2022.585
Dimensions
PlumX
license

Ninguna publicación, nacional o extranjera, podrá reproducir ni traducir sus artículos ni sus resúmenes sin previa autorización escrita del editor; sin embargo  los usuarios pueden descargar la información contenida en ella, pero deben darle atribución o reconocimiento de propiedad intelectual, deben usarlo tal como está, sin derivación alguna.

Dr. Juan José Chaves
Médico. Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Bogotá, Colombia.
    https://orcid.org/0000-0002-2905-3849
    Dr. Carlos Carvajal
    Especialista en Cirugía de Tórax. Departamento de Cirugía Torácica, Instituto Nacional de Cancerología, Bogotá, Colombia.
      https://orcid.org/0000-0001-5915-0052
      Dr. Rafael Parra-Medina
      Doctorado en Ciencias Biomédicas. Departamento de Patología, Instituto Nacional de Cancerología, Bogotá, Colombia. Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Bogotá, Colombia
        https://orcid.org/0000-0002-8428-5837
        Show authors biography

        Primary adenocarcinoma of the lung with signet-ring cells represents a rare and highly aggressive variant of lung cancer. Signet‐ring cell carcinoma is a particular type of mucin‐secreting adenocarcinoma, which is deposited intracytoplasmatically and displaces the nucleus towards the periphery of the cell. The pulmonary origin of this tumor subtype is rare, and the finding of ALK rearrangement is a common association. We present two cases of primary mucinous adenocarcinomas of the lung with signet-ring cells and ALK rearrangement. All patients with lung cancer must have histopathological, immunohistochemical, and molecular biology studies with which the main features of the tumor can be obtained, which allow the clinician to offer the best possible treatment for the patient.

        Article visits 2414 | PDF visits 1142

        Downloads

        Download data is not yet available.
        1. Testori A, Perroni G, Carlo C de, Crepaldi A, Alloisio M, Cioffi U. Primary signet‐ring cell carcinoma of the lung in an HIV‐positive patient. Thoracic Cancer [Internet]. 2021 Apr 16;12(7):1122–5. doi: 10.1111/1759-7714.13887
        2. Boland JM, Wampfler JA, Jang JS, Wang X, Erickson-Johnson MR, Oliveira AM, et al. Pulmonary adenocarcinoma with signet ring cell features. American Journal of Surgical Pathology. 2014 Dec;38(12):1681-8. doi: 10.1097/PAS.0000000000000280.
        3. Wu SG, Chen XT, Zhang WW, Sun JY, Li FY, He ZY, et al. Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis. Expert Review of Gastroenterology & Hepatology [Internet]. 2018 Feb 17;12(2):209–14. doi: 10.1080/17474124.2018.1416291.
        4. Kish JK, Ro JY, Ayala AG, McMurtrey MJ. Primary mucinous adenocarcinoma of the lung with signet-ring cells: A histochemical comparison with signet-ring cell carcinomas of other sites. Human Pathology [Internet]. 1989 Nov;20(11):1097–102. doi: 10.1016/0046-8177(89)90229-3.
        5. Yigit N, Celik E, Yavan I. Prominent signet ring cell morphology in a pulmonary squamous cell carcinoma. Turkish Journal of Pathology [Internet]. 2018;34(2):194-197. doi: 10.5146/tjpath.2015.01337.
        6. Yoshida A, Tsuta K, Nakamura H, Kohno T, Takahashi F, Asamura H, et al. Comprehensive Histologic Analysis of ALK-Rearranged Lung Carcinomas. American Journal of Surgical Pathology [Internet]. 2011 Aug;35(8):1226–34. doi: 10.1097/PAS.0b013e3182233e06.
        7. Laforga JBM. Foamy macrophages in pylorocardiac gastric carcinoma: a source of confusion with signet ring cell carcinoma. Histopathology. 2003 Jul;43(1):98–100. doi: 10.1046/j.1365-2559.2003.01638.x.
        8. Devarakonda S, Morgensztern D, Govindan R. Genomic alterations in lung adenocarcinoma. The Lancet Oncology [Internet]. 2015 Jul;16(7):e342–51. doi: 10.1016/S1470-2045(15)00077-7.
        9. Jiang F, Wang C, Yang P, Sun P, Liu J. Pathological cytomorphologic features and the percentage of ALK FISH-positive cells predict pulmonary adenocarcinoma prognosis: a prospective cohort study. World Journal of Surgical Oncology. 2021 Dec 16;19(1):278. doi: 10.1186/s12957-021-02386-0.
        10. Board WC of TE. Thoracic Tumours WHO Classification of Tumours, 5th Edition, Volume 5. 2021.
        11. Kocas O, Selcukbiricik F, Bilici A, Kanıtez M, Yildiz S, Avci S, et al. Primary Signet Ring Cell Carcinoma of the Lung with Cerebellar Metastasis Showing Full Response to Cisplatin and Docetaxel Therapy. Case Reports in Oncological Medicine [Internet]. 2014;2014:1–3. doi: 10.1155/2014/968723.
        12. Cai Y, Xie Y, Xiong Y, Guan W, Pu Y, Wang D, et al. Clinicopathological characteristics and survival in lung signet ring cell carcinoma: a population-based study. Bosnian Journal of Basic Medical Sciences [Internet]. 2021 Dec 1;21(6):752-759. doi: 10.17305/bjbms.2020.5454.
        13. Ou SHI, Ziogas A, Zell JA. Primary Signet-Ring Carcinoma (SRC) of the Lung: A Population-Based Epidemiologic Study of 262 Cases with Comparison to Adenocarcinoma of the Lung. Journal of Thoracic Oncology. 2010 Apr;5(4):420–7. doi: 10.1097/JTO.0b013e3181ce3b93.
        14. Nishino M, Klepeis VE, Yeap BY, Bergethon K, Morales-Oyarvide V, Dias-Santagata D, et al. Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas. Modern Pathology. 2012 Nov 29;25(11):1462–72. doi: 10.1038/modpathol.2012.109
        15. Li Y, Li Y, Yang T, Wei S, Wang J, Wang M, et al. Clinical Significance of EML4-ALK Fusion Gene and Association with EGFR and KRAS Gene Mutations in 208 Chinese Patients with Non-Small Cell Lung Cancer. Viglietto G, editor. PLoS ONE. 2013 Jan 14;8(1):e52093. doi: 10.1371/journal.pone.0052093.
        16. Popat S, Gonzalez D, Min T, Swansbury J, Dainton M, Croud JG, et al. ALK translocation is associated with ALK immunoreactivity and extensive signet-ring morphology in primary lung adenocarcinoma. Lung Cancer. 2012 Mar;75(3):300–5. doi: 10.1016/j.lungcan.2011.07.017.
        17. Du X, Shao Y, Qin HF, Tai YH, Gao HJ. ALK- rearrangement in non-small-cell lung cancer (NSCLC). Thoracic Cancer [Internet]. 2018 Apr;9(4):423–30. doi: 10.1111/1759-7714.12613.
        18. Doebele RC, Pilling AB, Aisner DL, Kutateladze TG, Le AT, Weickhardt AJ, et al. Mechanisms of Resistance to Crizotinib in Patients with ALK Gene Rearranged Non–Small Cell Lung Cancer. Clinical Cancer Research [Internet]. 2012 Mar 1;18(5):1472–82. doi: 10.1158/1078-0432.CCR-11-2906.
        19. Shaw AT, Yeap BY, Solomon BJ, Riely GJ, Gainor J, Engelman JA, et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. The Lancet Oncology. 2011 Oct;12(11):1004–12. doi: 10.1016/S1470-2045(11)70232-7.
        20. Yildiz I. Liver and Pancreatic Injury in Response to ALK Inhibitors in a Patient with Primary Signet Ring Cell Carcinoma of the Lung: A Case Report. Case Reports in Oncology [Internet]. 2021 Feb 26;14(1):107–11. doi: 10.1159/000512829.

        Information

        Journal history

        Keywords

        Directories and indexes

        Funding

        Support + Info: Here

         

         

        Google Scholar profile

        Most read in the last 30 days

        Current Issue

        QR code

        Sistema OJS 3.4.0.7 - Metabiblioteca |