Hipótesis higienista

Andrés Fabián Velasco Oliveros, MD.; Sergio Díaz Martínez, MD.; Robin Rada Escobar, MD.

doi:10.30789/rcneumologia.v23.n3.2011.210

The hygienist hypothesis

Hipótesis higienista

Published 2011-09-30

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Vol. 23 No. 3 (2011)

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Revisión de tema

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The hygienist hypothesis.

rev. colomb. neumol. [Internet]. 2011 Sep. 30 [cited 2024 Dec. 22];23(3):73-9. Disponible en: https://doi.org/10.30789/rcneumologia.v23.n3.2011.210

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https://doi.org/10.30789/rcneumologia.v23.n3.2011.210

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Andrés Fabián Velasco Oliveros, MD.

Universidad Militar Nueva Granada. Hospital Militar Central, Bogotá.

Sergio Díaz Martínez, MD.

Universidad Militar Nueva Granada. Hospital Militar Central, Bogotá.

Robin Rada Escobar, MD.

Hospital Militar Central. Bogotá, Colombia.

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Andrés Fabián Velasco Oliveros, MD.,

Médico Universidad Militar Nueva Granada. Hospital Militar Central, Bogotá.

Sergio Díaz Martínez, MD.,

Médico Universidad Militar Nueva Granada. Hospital Militar Central, Bogotá.

Robin Rada Escobar, MD.,

Internista Neumólogo Jefe Servicio de Medicina Interna. Hospital Militar Central. Bogotá, Colombia.

genetics

environment

immune response

allergy

The hygienist hypothesis suggests that environmental changes in the industrialized world have reduced exposure to microbes at early ages, thus increasing allergic diseases such as atopic eczema, allergic rhinoconjuntivitis, asthma (1), atopic dermatitis, and allergic gastroenteropathy (2,3). In the 1990s, epidemiologic findings were combined with the Th1/Th2 paradigm of immune response (4) to provide a coherent theory. Recent advancements in epidemiology, immunology, and genetics are the mainstay of this hypothesis.

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