Lymphocytic interstitial pneumonia associated with systemic lupus erythematosus. An uncommon, but not inexistent condition
Neumonía intersticial linfocítica asociada a lupus eritematoso sistémico. Una neumopatía infrecuente pero no inexistente
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Lymphocytic interstitial pneumonia is an uncommon condition characterized by non-neoplastic lymphoid hyperplasia of the interstitial lymphoid tissue of the lung. It is associated with autoimmune phenomena or viral infections, human immunodeficiency virus or mononucleosis, as well as systemic lupus erythematosus, although it is uncommon. The symptoms vary: dry cough, chest pain, dyspnea, and, less often, fever, arthralgia, and weight loss.
We present the case of a 40-year old female with a background of systemic lupus erythematosus diagnosed in 1998, who presented with pulmonary illness consistent with lymphocytic interstitial pneumonia, confirmed by clinical, radiologic, and histopathologic findings. She was treated with corticoids, cyclophosphamide, azathioprine, and immunoglobulin; however, due to her compromised immunologic system, she has developed several infectious complications.
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- Johkoh T, Müller NL, Pickford HA et al. Lymphocytic interstitial pneumonia: thin-section CT findings in 22 patients. Radiology. 1999;212(2):567-72.
- Swigris JJ, Berry GJ, Raffin TA, Kuschner WG. Lymphoid interstitiael pneumonia: a narrative review. Chest. 2002;122:2150-64.
- Franquet T, Giménez A. Neumonías intersticiales idiopáticas. Radiología. 2012; 54(6):479-89.
- Davies CW, Juniper MC, Gray W, et al. Lymphoid interstitial pneumonitis associated with common variable hypogammaglobulinemia trated with cyclosporine A. Thorax. 2000;55:88-90.
- Liebow AA, Carrington CB. Diffuse pulmonary lymphoreticular infiltrations associated with dysproteinemia. Med Clin North Am. 1973;57:809-43.
- Travis WD, Fox CH, Devaney KO, et al. Lymphoid pneumonitis in 50 adult patients infected with the human immunodeficiency virus: lymphocytic interstitial pneumonitis versus nonspecific interstitial pneumonitis. Hum Pathol. 1992;23:529-41.
- Church JA, Isaacs H, Saxon A, Keens TG, Richards W. Lymphoid interstitial pneumonitis and hypogammaglobulinemia in children. Am Rev Respir Dis. 1981;124:491-6.
- Cha SI, Fessler MB, Cool CD, Schwarz MI, Brown KK. Lymphoid interstitial pneumonia: clinical features, associations and prognosis. Eur Respir J. 2006;28:364-9.
- Gómez L. Enfermedades intersticiales en las conectivopatías. Rev Patol Respir. 2014;17(Supl.1):S53-S55.
- Strimlan CV, Rosenow EC, Weiland LH, Brown LR. Lymphocytic interstitial pneumonitis. Review of 13 cases. Ann Intern Med. 1978;88:616-21.
- Koss MN, Hochholzer L, Langloss JM, Wehunt WD, Lazarus AA. Lymphoid interstitial pneumonia: clinicopathological and immunopathological findings in 18 cases. Pathology. 1987;19:178-85.
- Mueller-Mang C, Grosse C, Schmid K, Stiebellehner L, Bankier AA. What every radiologist should know about idiopathic interstitial pneumonias. Radiographics. 2007;27:595-615.
- Zamora AC, Collard HR, Ryu JH, et al. HRCT appearance predicts the underlying etiology of lymphocytic interstitial pneumonia (abstract). San Francisco, CA. ATS, Mayo; 2007.
- Kondoh y, Taniguchi H, Yokoi T, et al. Cyclosphosphamide and low-dose prednisolone in idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumonia. Eur Respir J. 2005:25:528.
- Gómez L, Bonilla G. Manifestaciones pulmonares de las enfermedades del colágeno. Arch Bronconeumol. 2013;49(6):249–60.
- Ysamat R, Benito YA, Espejo PS, Blanco NM, Roldan MR. La patología pulmonar asociada a las enfermedades del tejido conectivo. Radiología. 2013;55(2):107-17.
- Zambrano GJA et al. Manifestaciones pulmonares en lupus eritematoso generalizado. Rev Med Hosp Gen Mex. 2004;67(1):41-9.
- Koss MN, Hochholzer L, Langloss JM, et al. Lymphoid interstitial pneumonia: clinicopathological and immunopathological findings in 18 cases. Pathology. 1987;19:178.
- Nanki N, Fujita J, Yamaji Y, et al. Nonspecific interstitial pneumonia/fibrosis completely recovered by adding cyclophosphamide to corticosteroids. Intern Med 2002:41:867.
- Peralta G, Villagomez R, Bosio M, et al. Neumonía intesticial linfoide asociada a inmunodeficiencia común variable. MEDICINA (Buenos aires). 2011;71;462-4.
- Strimlam CV, Rosenow EC, Weiland, LH, et al. Lymphocytic interstitial pneumonitis: A review of 13 cases. Ann Intern Med.
- ;68:616.