Fracción de óxido nítrico exhalado como biomarcador en asma

Fraction of exhaled nitric oxide as biomarker in asthma

Contenido principal del artículo

Gustavo Adolfo Hincapié Díaz, MD.
Javier Iván Lasso Apráez, MD.

Resumen

El asma es un síndrome heterogéneo en el cual la identificación y utilización de biomarcadores, puede contribuir a agrupar los pacientes en fenotipos y predecir quienes responderán a una terapia específica y evaluar además la respuesta al tratamiento. Un biomarcador ideal debe tener relevancia clínica, alta sensibilidad, ser confiable, repetible, simple, rápido, económico y contar con buena correlación con la respuesta al tratamiento. Se describen los diferentes biomarcadores utilizados en asma y se profundiza en la fracción de óxido nítrico exhalado su fisiopatología y utilidad clínica en el abordaje de pacientes asmáticos, su biosíntesis y regulación, su relación con la inflamación en el asma, se describen los estudios relacionados con el diagnóstico del asma y la fracción exhalada de óxido nítrico y como puede servir como herramienta para iniciar el tratamiento, cuáles son sus valores normales y los avances en la estandarización de la medición que han permitido que se convierta en un biomarcador que permite evaluar la inflamación de la vías aéreas.

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Biografía del autor/a (VER)

Gustavo Adolfo Hincapié Díaz, MD., Hospital Militar Central. Universidad Nueva Granada. Bogotá, Colombia.

Coordinador del Servicio de Neumología del Hospital Militar Central. Profesor Asociado de la Universidad Nueva Granada. Bogotá, Colombia.

Javier Iván Lasso Apráez, MD., Hospital Universitario San Ignacio. Pontificia Universidad Javeriana. Bogotá, Colombia.

Internista. Neumólogo del Hospital Universitario San Ignacio. Profesor ad-honorem de la Pontificia Universidad Javeriana. Bogotá, Colombia.

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