Inconclusa historia del asma

Gustavo Adolfo Gómez Correa


En esta revisión se describen la etiología y la naturaleza del asma en el contexto histórico, la patología y fisiopatología en el tiempo y cómo se ha desarrollado el concepto de la terapia en el asma. Desde tiempos antiguos, el asma ha sido reconocida por muchas culturas, incluidas la china, la hebrea, la griega y la romana. Fue el médico griego Hipócrates (460-377 a. C.) de los primeros en describirla, aunque el término era usado para referirse a un síntoma y no a una enfermedad. La mayor contribución para el entendimiento del asma en el siglo XIX fue hecha por Henry Hyde Salter (1823-1871 d. C.), quien propuso una clasificación de asma intrínseca y extrínseca basado en el mecanismo y la naturaleza de varios estímulos. William Osler (1849-1919 d. C.) describió la relación entre los diferentes estímulos que causan disfunción paroxística de las vías aéreas en el asma.

Palabras clave

historia del asma; xantinas; anticolinérgicos; broncodilatadores adrenérgicos; corticosteroides; antileucotrienos; cromonas

Texto completo:



A controlled trial of inhaled corticosteroids in patients receiving Prednisone tablets for asthma. Br J Dis Chest. 1976;70(2):95-103.

Alexander HL. A historical account of death from asthma. J Allergy. 1963;34:305-22.

Jackson M. Allergy: the history of a modern malady. Londres: Reaktion Books Ltd.; 2006.

Jackson M. Asthma: the biography. Nueva York: Oxford University Press; 2009.

Bergmann KC. Asthma. Chem Immunol Allergy. 2014;100:69-80.

Diamant Z, Boot JD, Virchow JC. Summing up 100 years of asthma. Respir Med. 2007;101(3):378-88.

Cserháti E. The history of bronchial asthma from the ancient times till the Middle Ages. Acta Physiol Hung. 2004;91(3-4):243-61.

Cserháti E. The history of bronchial asthma from the Renaissance till the beginning of the twentieth century. Acta Physiol Hung. 2005;92(2):181-92.

Ellul-Micalle R. Asthma: a look at the past. Br J Dis Chest. 1976;70(2):112-6.

Falliers CJ. The origins of asthma and its clinical “cures”. J Asthma. 1982;19(4):227-8.

Marketos SG, Ballas CN. Bronchial asthma in the medical literature of Greek antiquity. J Asthma. 1982;19(4):263-9.

Cohen SG. Asthma in antiquity, the Ebers Papyrus. Allergy Proc. 1992;13(3):147-54.

Cohen SG. Asthma and obesity: an archival addendum. J Allergy Clin Immunol. 2009;123(1):265-6; author reply 266.

Cohen SG. Blocking asthmatic progression and chronicity in the pre-corticosteroid era. J Allergy Clin Immunol. 2008;121(3):787-90.

Cohen SG. Asthma and athletics. J Allergy Clin Immunol. 2008;122(2):435-9, 439.e1-3.

McFadden ER Jr. A century of asthma. Am J Respir Crit Care Med. 2005;170(3):215-21.

Osler W. Bronchial asthma. Principles and practice of medicine. Nueva York: D. Appleton & Co.; 1892.

Chu EK, Drazen JM. Asthma: a one hundred years of treatment and onward. Am J Respir Crit Care Med. 2005;171(11):1202-8.

Floyer JS. A treatise of the asthma. Divided into four parts printed for Richard Wilkin at St. Pauls’ Churchyard, London. 1698.

20. Murtagh P. Asma: ayer y hoy. Arch Argent Pediatr. 009;107(2):146-51.

Neale AV. Some thoughts and experiments on respiration and on asthma, with special reference to Henry Hyde Salter. Med Hist. 1963;7:247-57.

Persson CGA. On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter. Thorax. 1985;40(12):881-6.

Sakula A. Henry Hyde Salter (1823-71): a biographical sketch. Thorax. 1985;40(12):887-8.

Salter HH. On asthma: its pathology and treatment. Londres: John Churchill; 1860.

Sakula A. Charcot-Leyden crystals and Curschmann spirals in asthmatic sputum. Thorax. 1986;41(7):503-7.

Kay AB. The early history of the eosinophil. Clin Exp Allergy. 2015;45(3):575-82.

Schwartz RS. Paul Ehrlich’s magic bullets. N Engl J Med. 2004;350(11):1079-80.

Ring J, Gutermuth J. 100 years of hyposensitization: history of allergen-specific immunotherapy (ASIT). Allergy. 2011;66(6):713-24.

Fowler JK, Godlee RJ. Asthma. En: The diseases of the lungs. Nueva York: Longmans, Green, and Company; 1898. p. 183-94.

Holgate ST. Lessons learnt from the epidemic of asthma. QJM. 2004;97(5):247-57.

Holgate ST. Asthma: a simple concept but in reality a complex disease. Eur J Clin Invest. 2011;41(12):1339-52.

Huber HL, Koessler KK. The pathology of bronchial asthma. Arch Intern Med. 1922;30(6): 689-760.

Dunnill MS. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol. 1960;13:27-33.

Dale HH, Laidlaw PP. The physiological action of β-iminazolylethylamine. J Physiol. 1911;41(5):318-44.

Curry JJ. The action of histamine on the respiratory tract in normal and asthmatic subjects. J Clin Invest. 1946;25(6):785-91.

Riley J, West GB. Histamine and tissue mast cells. J Physiol. 1953;117(4):72P-73P.

Ishizaka K, Ishizaka T, Hornbrook MM. Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J Immunol. 1966;97(1):75-85.

Voorhorst R, Spieksma F, Varekamp H, et al. The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen. J Allergy. 1967;39(6):325-39.

Ellul-Micallef R. Airway smooth muscle in health and in asthma. Br J Dis Chest. 1973;67(2):107-13.

Laitinen LA, Heino M, Laitinen A, Kava T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis. 1985;131(4):599-606.

Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammations. Science. 1983;220(4597):568-75.

Weiss JW, Drazen JM, Coles N, McFadden ER Jr, Weller PF, Corey EJ, et al. Bronchoconstrictor effects of leukotriene C in humans. Science. 1982;216(4542):196-8.

Brown OH. Treatment of asthma. En: Brown OH. Asthma: presenting an exposition of the non-passive expiration theory. St Louis: C.V. Mosby; 1917. p. 265-88.

Anderson PJ. History of aerosol therapy. Liquid nebulization to MDIs to DPIs. Respir Care. 2005;50(9):1139-50.

Jackson M. “Divine stramonium”: the rise and fall of smoking for asthma. Med Hist. 2010;54(2):171-94.

Herrmann G, Aynesworth MB. Successful treatment of persistent extreme dyspnea “status asthmaticus”: use of theophylline ethylene diamine (aminophylline, USP) intravenously. J Lab Clin Med. 1937;23:135-48.

Siegel SC. History of asthma deaths from antiquity. J Allergy Clin Immunol. 1987;80(3 Pt 2):458-62.

Stewart TG, Gibson GA. Asthma. En: Stedman TL (editor). Twentieth century practice: an international encyclopedia of modern medical science by leading authorities of Europe and America. Volumen VI. Nueva York: William Wood and Co; 1896. p. 585-617.

Gross MJ. Sch 1000: a new anticholinergic bronchodilator. Am Rev Respir Dis. 1975;112(6):823-8.

Sanders M. Inhalation therapy: an historical review. Prim Care Respir J. 2007;2(16):71-81.

Solis-Cohen S. The use of adrenal substance in the treatment of asthma. JAMA 1900;34:1164-6.

Solis-Cohen S. The use of adrenal substance in the treatment of asthma. 1900. J Asthma. 1990;27(6):401-6.

Barger G, Dale HH. Chemical structure and sympathomimetic action of amines. J Physiol. 1910;41(1-2):19-59.

Hui KK, Barolet-Garcia C. A patient with asthma seeks medical advice. N Engl J Med. 2012;366(18):1741-2; author reply 1742.

Kagouridis K. A patient with asthma seeks medical advice. N Engl J Med. 2012;366(18):1740; author reply 1742.

O’Sullivan BP, Zwerdling RG, Kremer T. A patient with asthma seeks medical advice. N Engl J Med. 2012;366(18):1740; author reply 1742.

Simons SM. A patient with asthma seeks medical advice. N Engl J Med. 2012;366(18):1741; author reply 1742.

von Mutius E, Drazen JM. A patient with asthma seeks medical advice in 1828, 1928, and 2012. N Engl J Med. 2012;366(9):827-34.

Melland B. The treatment of spasmodic asthma by the hypodermic injection of adrenalin. Lancet. 1910;i:1407-11.

Pérez-Martín J. Cronología de los medicamentos para el asma. Rev Alerg Mex. 1999;46(6):152-4.

National Library of Medicine. National Institutes of Health. U.S. Department of Health and Human Services. Breathe of life. Washington.

Gay LN, Long JW. Clinical evaluation of isopropyl-epine- phrine in management of bronchial asthma. J Am Med Assoc. 1949;139(7):452-7.

Persson CG. In vivo veritas: the continuing importance of discoveries in complex biosystems. Thorax. 1996;51(4):441-3.

Persson CG. Astute observers discover anti-asthma drugs. Pharmacol Toxicol. 1995;77 Suppl 3:7-15.

Waldeck B. Beta-adrenoceptor agonists and asthma—100 years of development. Eur J Pharmacol. 2002;445(1-2):1-12.

Ahlquist RP. A study of the adrenotropic receptors. Am J Physiol. 1948;153(3):586-600.

Rau JL. Inhaled adrenergic bronchodilators: historical development and clinical application. Respir Care. 2000;45(7):854-63.

Rossing TH, Fanta CH, Goldstein DH, Snapper JR, McFadden ER Jr. Emergency therapy of asthma: comparison of the acute effects of parenteral and inhaled sympathomimetics and infused aminophylline. Am Rev Respir Dis. 1980;122(3):365-71.

Barnes PJ, Breckenridge A. David Jack (1924-2011) who revolutionised the treatment of asthma. Thorax. 2012;67(3):266-7.

Page C, Humphrey P. Sir David Jack: an extraordinary drug discoverer and developer. Br J Clin Pharmacol. 2012;75(5):1213-8.

Cromptom G. A brief history of inhaled asthma therapy over the last fifty years. Prim Care Respir J. 2006;2(15):326-31.

Tattersfield AE. Current issues with beta2-adrenoceptor agonists: historical background. Clin Rev Allergy Immunol. 2006;31(2-3):107-18.

Schwartz E. Oral cortisone therapy in intractable bronchial asthma. J Am Med Assoc. 1951;147(18):1734-7.

McCombs RP. Serial courses of corticotrophin or cortisone in chronic bronchial asthma. N Engl J Med. 1952;247(1):1-6.

Brown HM. How the first effective inhaled corticosteroid was almost discarded as useless. Ann Allergy Asthma Immunol. 2007;98(6):602-3.

Brown HM, Storey G, George WH. Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. Br Med J. 1972;1(5800):585-90.

Clark TJ. Effect of beclomethasone dipropionate delivered by aerosol in patients with asthma. Lancet. 1972;1(7765):1361-4.

Partridge MR. Asthma 1987-2007. What have we achieved and what are the persisting challenges? Prim Care Respir J. 2007;2(16):145-8.

Inhaled corticosteroids compared with oral prednisone in patients starting long-term corticosteroid therapy for asthma. A controlled trial by the British Thoracic and Tuberculosis Association. Lancet. 1975;2(7933):469-73.

Davies G, Thomas P, Broder I, Mintz S, Silverman F, Leznoff A, et al. Steroid-dependent asthma treated with inhaled beclomethasone diproprionate. Ann Intern Med. 1977;86:549-53.

Wyatt R, Waschek J, Weinberger M, Sherman B. Effects of inhaled beclomethasone dipropionate and alternate-day prednisone on pituitary adrenal function in children with chronic asthma. N Engl J Med. 1978;299(25):1387-92.

O`Byrne PM, Nair P, Sterk PJ. In memoriam: Frederick E Hargreave (1938-2011). Thorax 2011;66(12):1101-2.

Persson CG. Glucocorticoids for asthma--early contributions. Pulm Pharmacol. 1989;2(3):163-6.

Raji MA. The nervous system as potential targets for asthma treatments: lessons learned from a centennial history of asthma research. Am J Respir Cell Mol Biol. 2005;33(2):211.

Walter M. A Centennial History of Research on Asthma Pathogenesis. Am J Respir Cell Mol Biol. 2005;(32):483-9.

Orr TS. Mast cells and allergic asthma. Br J Dis Chest. 1973;67(2):87-106.

Edwards AM. Gleb von Anrep. J R Soc Med. 1998;91(6):345.

Yentis SM. Minds and hearts: themes in the life of Gleb von Anrep. J R Soc Med. 1998;91(4):209-12.

Edwards AM, Howell JB. The chromones: history, chemistry and clinical development. A tribute to the work of Dr R. E. C. Altounyan. Clin Exp Allergy. 2000;30(6):756-74.

Howell JB, Altounyan RE. A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet. 1967;2(7515):539-42.

Cespedes B, Restrepo A, Restrepo B, Vieira T. Índice de la literatura médica colombiana 1890-1960. Bogotá: ASCOFAME; Ediciones Tercer Mundo; 1964.

Arango MS. Dos casos de asma tratados por autoterapia. Rev Med Bogotá. 1918;36(429/432):100-65.

Arbeláez H. El asma infantil y su tratamiento por los rayos ul- travioleta. Medellín: Clínica Gil. Medellín; 1926. p. 373-376.

Barrios H. Estados asmatiformes en el lactante. Rev Med Cir Barranquilla. 1949;16(10):13-8.

Camacho A. Asmas. Diagnóstico. Etiología, patogenia y tratamiento. Medicina. Bogota. 1939;1(5):131-9.

Castro G. Algunas consideraciones sobre el asma bronquial. Medicina y Ciencias Afines. Bogotá. 1958;9(1):1-26.

Cuba TM. Asma no es ninguna entidad nosológica. Cartagena: Clínica Vargas; 1953. p. 36-41.

Jordán R. Estudio del cuajaní y su aplicación en el asma esencial. Medellín: Labor; 1927. p. 121-7.

Meluk T. El asma bronquial; aspectos psicosomáticos. El Médico. Bogotá. 1958;2(10):9-16.

Méndez M. Algo sobre el tratamiento del asma esencial por las inyecciones de adrenalina. Repertorio de Medicina y Cirugía. Bogotá. 1917;8(12):554-8.

Restrepo JM. Síndrome asmático y factores psíquicos. Antioquia Médica. Medellín. 1957;7:487-95.

Restrepo N. Asma y asmáticos. Revista Facultad de Medicina. Bogotá. 1943;11(11):635-44.

Rodríguez E. Terapéutica etiopatológica del asma. Orientaciones Médicas. Medellín. 1954;3:263-5.

Ruiz G. La dieta del asmático. Revista de Medicina y Cirugía. Barranquilla. 1937;4(3):10-21.

Trujillo C. El determinismo de las crisis de asma anafiláctico y coloidoclásico. Repertorio de Medicina y Cirugía. Bogotá. 1924;15(10):529-36.

Valero C. El asma y sus tratamientos. Medicina y Cirugía. Bogotá. 1942;6(5):207-14.

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