Avances en la selección de donantes para el trasplante pulmonar

Ricardo Zapata González, MD., lker López Sanz, MD., Cristina Berastegul Garcia, MD., Juan Sole Montserrat, MD., Nuria Masnou Burrallo, MD., Maria Deu Martln, MD., Laura Romero Vlelva, MD., Alberto Jauregui Aburalach, MD., Antonio Román Broto, MD., Mercedes Canela Cardona, MD.

Resumen


La obtención de donantes pulmonares válidos continúa siendo un reto en el trasplante pulmonar. En los centros trasplantadores con larga trayectoria, una de las opciones que ha permitido aumentar el número de trasplantes pulmonares por año, ha sido la extensión de los criterios de aceptabilidad para los donantes. En este artículo se hace un repaso minucioso de cada criterio por separado y de la posible influencia en los resultados del trasplante a corto y largo plazo; Igualmente, se revisan los datos actuales de donación y trasplante en España.


Palabras clave


trasplante; donante; selección

Texto completo:

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Referencias


Morell F, Roman A, Bravo C, Nicolau F, Marti S. The results of the evaluation of 208 patients referred In the first 4 years to a lung transplantation program. The Lung Transplantation Group of Hospital Vall d'Hebron. Arch Bronconeumol. 1996; 32 (6): 280-284.

Roman A, Morell F, Astudillo J, Margarit C, Bravo c. Tenorio L. et al. Unilateral lung transplantation: the first 2 cases. Group of Lung Transplantation of lhe University General Hospital of the Van d'Hebron. Med Clin (Barc). 1993; 100 (10): 380-383.

Moren F, Astudillo J, Roman A. The lung transplanl. Med Clin (Barc). 1993; 100 (14): 545-546.

Trulock EP. Lung transplantation. Am J Respir Crit Care Med. 1997; 155 (3): 789-818.

Arcasoy SM, Kotloff RM. Lung transplantation. N Engl J Med. 1999; 340 (14): 1081-1091.

Garrido-Cantarero G, Matesanz-Acedos R Epidemiology of transplantation In Spain. Enferm lnfecc Microbio! Clin. 2007; 25 (1): 54-62.

Coll E, Santos F, Ussetti P. Canela M, Borro JM, De La Torre M et al. The Spanish Lung Transplant Registry: First Report of Results (2006-2010). Arch Bronconeumol. 2012.

Christie JD, Edwards LB, Kucheryavaya AY, Benden C, Dobbels F, Kirk Retal. The Registry of the lnternational Society for Heart and Lung Transplantation: Twenty-eighth Adult Lung and Heart-Lung Transplanl Report--2011. J Heart Lung Transplant. 2011; 30 (10): 1104-1122.

Weill D. Donor crileria in lung transplantation: an íssue revisited. Chest. 2002; 121 (6): 2029-2031.

Date H, Aoe M, Nagahiro 1, Sano Y, Andou A, Matsubara H et al. Livíng-donor lobar lung transplantation for various lung diseases. J Thorac Cardiovasc Surg. 2003; 126 (2): 476-481.

Date H, Shiraishi T, Sugimoto S, Shoji T, Chen F, Hiratsuka M et al. Outcome of líving-donor lobar lung transplantation using a single donar. J Thorac Cardiovasc Surg. 2012; 144 (3): 710-715.

Bando T. Date H, Mínamí M, Kondo T, Shiraíshi T. Miyoshl Set al. First registry report: lung transplantation in Japan: The Japanese Society of Lung and Heart-Lung Transplantation. Gen Thorac Cardiovasc Surg. 2008; 56 (1): 17 -21.

de Antonio DG, Marcos R, Laporta R, Mora G, García-Gallo C, Gamez P et al. Results of clinical lung transplant from uncontrolled non-heart-beating donors. J Heart Lung Transplanl. 2007; 26 (5): 529-534.

Gomez-de-Antonio D, Campo-Canaveral JL, Crowley S, Valdivia D, Cordoba M, Moradienos J el al. Cllnical lung transplantation from uncontrolled non-heart-beating donors revisiled. J Heart Lung Transplant. 2012; 31 (4): 349-353.

Christie JD, Edwards LB, Kucheryavaya AY, Benden C. Dobbels F. Kirk R et al. The Registry of the lnternational Society for Heart and Lung Transplantation: Twenty-eighth Adull Lung and Heart-Lung Transplant Report-2011. J Heart Lung Transplant. 2011: 30 (10): 1104-1122.

Coll E, Miranda B. Domlnguez-Gil B, Martín E, Valentin M, Garrido G, el al. Organ donors In Spain: evolutíon of donation rates per regions and determinant factors. Med Clin (Barc). 2008; 131 (2): 52-59.

Orens JB, Boehler A, de Perro! M. Estenne M, Glanville AR, Keshavjee S et al. A review of lung transplant donor acceptabilíty criteria. J Heart Lung Transplant. 2003; 22: 1183-1200.

Snell GI, Westall GP. Selection and management of the lung donar. Clin Chest Med. 2011; 32 (2): 223-232.

Snell GI, Westall GP. Donar selection and management. Curr Opin Organ Transplant. 2009; 14 (5): 471-476.

Minambres E, Zurbano F, Naranjo S, González-Castro A, Mons R, González-Fernández C et al. Lung transplantation using donors 55 years and older. Med Intensiva. 2011; 35 (7): 403-409.

Filosso PL, Turello O, Cavallo A, Ruffini E, Mancuso M, Oliaro A. Lung donors selection críteria: a review. J Cardiovasc Surg (Torino). 2006; 47 (3): 361-366.

Aigner C. Winkler G, Jaksch P. Seebacher G. Lang G, Taghavi S et al. Extended donar criteria for lung transplantation - a clinical reality. Eur J Cardiothorac Surg. 2005; 27 (5): 757-761.

Botha P, Fisher AJ, Dark JH. Marginal lung donors: Adminishing margin of safety? Transplantation. 2006; 82 (10): 1273-1279.

Garrido-Cantarero G, Matesanz-Acedos R. Epidemiology of transplantation in Spain. Enferm lnfecc Microbiol Clin. 2007; 25 (1): 54-62.

Wilkes OS, Egan TM. Reynolds HY. Lung transplantation: opporlunities for research and clinical advancement. Am J Respir Crit Care Med. 2005; 172: 944-955.

Minambres E, Ballesteros MA, Rodrigo E, Garcia-Miguelez A, Llorca J, Ruiz JC, et al. Aggressive lung donor management increases graft procurement without increasing renal graft loss after transplantation. Clin Transplanl. 2012.

Fischer S, Gohrbandt B, Struckmeier P, Niedermeyer J, Simon A, Hagl C et al. Lung transplantation with lungs from donors fifty years of age and older. J Thorac Cardiovasc Surg. 2005; 129 (4): 919-925.

Schiavon M, Falcoz PE, Santelmo N, Massard G. Does the use of extended criteria donors influence early and long-term results of lung transplantation? lnteract Cardiovasc Thorac Surg. 2012; 14 (2): 183-187.

Kawut SM, Reyentovich A, Wilt JS. Anzeck R, Lederer DJ, O'Shea MK, et al. Outcomes of extended donor lung recipients after lung transplantatlon. Transplantation. 2005; 79: 310-316.

Lardinois O. Banysch M, Korom s. Hillinger S, Rousson V, Boehler A et al. Extended donor lungs: eleven years experience in a consecutive series. Eur J Cardiothorac Surg. 2005; 27: 762-767.

Thabut G, Mal H, Cerrina J, Dartevelle P. Oromer C, Velly JF, et al. lnfluence of donor characteristics on outcome after lung transplantation: a multicenter study. J Heart Lung Transpiant. 2005; 24 (9): 1347-1353.

Freitas MC. Trend in lung transplantation in the U.S.: an analysis of the UNOS registry. Clin Transpl. 2010; 17-33.

Novick RJ, Bennett LE, Meyer OM, Hosenpud JO. lnfluence of graft lschemic time and donor age on survival after lung transplantation. J Heart Lung Transplant. 1999; 18 (5): 425-431.

Shumway SJ, Hertz MI, Petty MG, Bolman RM, III. Liberalization of donar criteria in lung and heart-lung transplantation. Ann Thorac Surg. 1994; 57 (1 ): 92-95.

Sundaresan S. Semenkovich J, Ochoa L. Richardson G, Trulock EP, Cooper JO et al. Successful outcome of lung transplantation is not compromised by the use of marginal donor lungs. J Thorac Cardiovasc Surg. 1995: 109: 1075-1079.

Thabut G, Mal H, Cerrina J, Oartevelle P, Dromer C, Velly JF: et al. lnfluence of donor characteristics on outcome after lung transplantation: a multicenter study. J Heart Lung Transplant 2005; 24 (9): 1347-1353.

Gabbay E, Williams T J, Griffiths AP, Macfarlane LM Kotsmbos TC, Esmore OS, et al. Maximizing the utillzation of donor organs

offered for lung transplantation. Am J Respir Crit Care Med 1999; 160: 265-271.

Aziz TM, El Gamel A, Saad RA, Migliore M, Campbell CS, Yonan NA. Pulmonary vein gas analysis for assessing donor lung function. Ann Thorac Surg. 2002; 73: 1599-1604.

Bolton JS, Padia SA, Borja MC. Becker P, Orens JB, Wiener C et al. The predictive value and inter-observer variability of donor chest radiograph interpretation in lung transplantation. Eur J Cardiothorac Surg. 2003; 23: 484-487.

Straznicka M, Follette OM, Eisner MO, Roberts PF, Menza RL, Babcock WD Aggressive management of lung donors classified as unacceptable: excellent reciplent survival one year after transplantation. J Thorac Cardiovasc Surg. 2002; 124: 250-258.

Egan TM, Boychuk JE, Rosato K. Cooper JO. Whence the lungs? A study to assess suitability of donor lungs for transplantation. Transplantation. 1992; 53 (2): 420-422.

Riou B, Guesde R, Jacquens Y, Ouranteau R, Viars P. Fiberoptic bronchoscopy in brain-dead organ donors. Am J Respir Crit Care Med. 1994; 150: 558-560.

Orens JB, Boehler A. de PM. Estenne M, Glanville AR. Keshavjee S et al. A review of lung transplant donar acceptability criteria. J Heart Lung Transplant. 2003; 22 (11): 1183-1200.

Harjula A. Baldwin JC, Starnes VA, Stinson EB, Oyer PE, Jamieson SW et al. Proper donar selection for heart-lung transplantation. The Stanford experience. J Thorac Cardiovasc Surg 1987; 94 (6): 874-880.

Griffith BP, Zenati M. The pulmonary donor. Clin Chest Med. 1990; 11 (2): 217-226.

Stewart S, Ciulli F, Wells FC, Wallwork J. Pathology of unused donor lungs. Transplant Proc. 1993; 25 (1 PI 2): 1167-1168.

Gavalda J, Reman A. lnfection in lung transplantation. Enferm lnfecc Microbio! Clin. 2007; 25 (10): 639-649.

Maurer JR, Tullls DE, Grossman RF, Vellend H, Winton TL, Patterson GA. lnfectious complicatíons following ísolated lung transplantation. Chest. 1992; 101 (4): 1056-1059

Chaparro C, Maurer J, Gutíérrez C, Krajden M. Chan C, Winton T, et al. lnfection with Burkholderia cepacia in cystic fibrosis: outcome following lung transplantation. Am J Respir Crit Care Med. 2001; 163 (1): 43-48.

Chamorro C, Aparicio M. lnfluence of anti-hbc positlve organ donar In lung donor selectíon. Arch Bronconeumol. 2012; 48 (9): 320-324.

Chamorro C, Aparicio M. lnfluence of HBcAb positivity in the organ donar In heart transplantation. Med Intensiva. 2012.

Bonser RS, Taylor R, Collett O, Thomas HL, Dark JH, Neuberger J. Effect of donor smoking on survival after lung transplantation: a cohort study of a prospectíve registry. Lancet. 2012; 380 (9843): 747-755.

Berman M, Goldsmith K, Jenkíns D, Sudarshan C, Catarino P. Sukumaran N et al. Comparison of outcomes from smoking and nonsmoking donors: thirteen-year experience. Ann Thorac Surg. 2010; 90 (6): 1786-1792

Oto T, Griffiths AP, lewey B, Pifcher DV, Whitford H, Kotsimbos TC et al A donor history of smoking affects early but not late outcome in lung transplantahon. Transplantahon. 2004, 78: 599-606.

Boyle P Cancer. cigarette smoking and prematura death in Europe: a review includinq the Recommendations of European Cancer Experts Consensus Meeting, Helsinki, October 1996. Lung

Cancer. 1997; 17 (1): 1-60.

Boyle P, Maisonneuve P. Lung cancer and tobacco smoking.

Lung Cancer. 1995; 12 (3): 167-181.

De Soyza AG Dark JH, Parums OV, Curtrs A, Coms PA. Donoracquired small cell lung cancer following pulmonary transplantation. Chest. 2001; 120 (3)· 1030-1031.

Arcasoy SM, Hersh c. Christie JD, Zisman O, Pochettino A. Rosengard BR et al. Bronchogenic carcinoma complicating lung transplantation. J Heart Lung Transplant. 2001, 20 (10): 1044-1053.

Buell JF, Trote J, Hanaway MJ, Lo A, Rosengard B, Rilo H et al. Transmission of donor cancer into cardiothoracic transplant recipients. Surgery. 2001, 130 (4) 660-666.

Penn l. Transmission of cancer from organ donors. Ann Transplant. 1997; 2 (4) 7-12.

García RA. Spain is to lead on EU policy on organ donation and transplantation. BMJ. 2011, 343: d4413.

Matesanz R, Miranda B. The Spanish model of organ donation: the National Organization of Transplants (ONT) Registry report 1994. Clin Transpl 1995; 111-115

Matesanz R. Marazuela R. Dommquez-Gil B, Coll E, Mahillo B, de la Rosa G. The 40 donors per million population plan: an action plan for improvement of organ donation and transplantation in Spain Transplant Proc. 2009; 41 (8): 3453-3456.

Chui AK, Herbertt K, Wang LS, Kyd G, Hodgeman G, Verran DJ et al Risk of tumor transmission in transplantation from donors with primary brain tumors: an Australian and New Zealand registry report. Transplant Proc. 1999; 31 (1-2): 1266-1267.

Oto T, Griffiths A. Lewey B. Whitford H, Kotstrnbos TC, Rabinov M et al. Donor history of asthma is not a contraindication to lung transplantation: 12-year single-center experience. J Heart Lung Transplant. 2004; 23. 309-316

Oto T, Rowland M, GriffithsAP, Levvey BJ, Esmore OS, Williams T J et al. Third-time lung transplant using extended criteria lungs. Ann Thorac Surg 2007; 84 (2): 642-644

Aigner C, Winkler G, Jaksch P, Seebacher G, Lang G, Taghavi S, et al. Extended donor criteria for lung transplantation -a clinical reality. Eur J Cardiothorac Surg 2005; 27· 757-761.

Thabut G, Mal H. Cerrina J, Dartevelle P, Dromer C, Velly JF et al. Graft ischemic time and outcome of lung transplantation: a mulhcenter analysis. Am J Respir Cnt Care Med. 2005; 171. 786-791.

Fiser SM, Kron IL, Long SM, Kaza AK Kern JA. Cassada DC et al. lnfluence of graft ischermc time on outcomes following lung transplantation. J Heart Lung Transplant 2001, 20 (12) 1291-1296.

Gammie JS. Stukus DR. Pham SM, Hattler BG, McGrath MF, McCurry KR et al. Effect of ischemic time on survival in clinical lung transplantatíon Ann Thorac Surg 1999, 68 (6). 2015-2019

Chamorro C, Falcon JA, Michelena JC. Controversial points on organ donor management. Transplant Proc. 2009; 41 (8): 3473-3475

Hicks M, Hing A, Gao L, Ryan J, Macdonald PS. Organ preservation. Methods Mol Biol. 2006; 333: 331-374

Sánchez PG, Bittle GJ, Burdorf L, Pierson RN, III, Griffith BP. State of art: clinical ex vivo lung perfusion: rationale, current status, and future directions. J Heart Lung Transptant 2012; 31 (4) 339-348.

Zych B, Popov AF, Stavri G. Bashford A, Bahrami T. Amrani M et al. Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning. J Heart Lung Transplant. 2012; 31 (3)· 274-281.

Wierup P, Haraldsson A, Nilsson F, Pierre L, Schersten H, Silverborn M, et al. Ex vivo evaluation of nonacceptable donor lungs. Ann Thorac Surg 2006; 81 (2): 460-466.

Cypel M, Yeung JC, Machuca T, Chen M, Singer LG, Yasufuku K et al. Experience with the first 50 ex vivo lung perfusions in clinical transplantation. J Thorac Cardiovasc Surg 2012.

Cypel M, Keshavjee S. The clinical potential of ex vivo lung perfusion. Expert Rev Respir Med. 2012; 6 (1): 27-35.

Cypel M, Rubacha M, Yeung J, Hirayama S, Torbicki K, Madonik M, et al. Normothermic ex vivo perfusion prevents lung lnjury compared to extended cold preservation for transplantation. Am J Transplant 2009, 9 (10): 2262-2269.

Cypel M, Keshavjee S. The clinical potential of ex vivo lung perfusion. Expert Rev Respir Med. 2012; 6 (1): 27-35.

Eberlem M, Reed RM. Permutt S, Chahla MF, Bolukbas S,

Nathan SD, et al. Parameters of donor-recipient size mismatch

and survival after bilateral lung transplantalion. J Heart Lung Transplant. 2011

Massard G, Badier M, Guillot C, Reynaud M, Thomas P, Giudicelli R, et al. Lung size matching for double lung transplantation based on the submammary thoracic perimeter. Accuracy and functional results. The Joint Marseille-Montreal Lung Transplant Program. J Thorac Cardiovasc Surg. 1993: 105 (1): 9-14.

Eberlein M, Arnaoutakis GJ, Yarmus L. Feller-Kopman D, Dezube R, Chahla MF, et al. The effect of lung size mismatch on complications and resource utilization after bilateral lung transplantation. J Heart Lung Transplant. 2012, 31 (5) 492-500.

Eberlein M, Permutt S, Chahla MF. Bolukbas S, Nathan SD, Shlobin OA et al. Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome. Chest 2012; 141 (2): 451-460.

Disponible en Internet: www.ont.es/infesp/Memorias/MemPulm6n2011.pdf. Último acceso enero 2013.

Disponible en Internet: www.gencat.cat/docs/canalsalut/Minisite/Trasplantament/lnforme%20donació%202011.pdf. Último acceso enero de 2013.




DOI: http://dx.doi.org/10.30789/rcneumologia.v24.n2.2012.184

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