Macrólidos en enfermedades inflamatorias crónicas de las vías respiratorias

Mauricio Moreno, MD.; Oscar Sáenz Morales, MD.; Camilo Manrique Martínez, MD.; Francisco González Acosta, MD.; Erika Paola Vergara Vela, MD.; Alberto Mario Pereira Garzón, MD.; Rafael Miranda Jiménez, MD.

doi:10.30789/rcneumologia.v23.n2.2011.178

Macrólidos en enfermedades inflamatorias crónicas de las vías respiratorias

Macrolides in chronic inflammatory diseases of the airway

Publicado 2011-06-20

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Vol. 23 Núm. 2 (2011)

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Macrólidos en enfermedades inflamatorias crónicas de las vías respiratorias.

rev. colomb. neumol. [Internet]. 2011 Jun. 20 [cited 2024 Dec. 4];23(2):40-7. Disponible en: https://doi.org/10.30789/rcneumologia.v23.n2.2011.178

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https://doi.org/10.30789/rcneumologia.v23.n2.2011.178

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Ninguna publicación, nacional o extranjera, podrá reproducir ni traducir sus artículos ni sus resúmenes sin previa autorización escrita del editor; sin embargo los usuarios pueden descargar la información contenida en ella, pero deben darle atribución o reconocimiento de propiedad intelectual, deben usarlo tal como está, sin derivación alguna.

Mauricio Moreno, MD.

Hospital Santa Clara. Bogotá, Colombia.

Oscar Sáenz Morales, MD.

Hospital Santa Clara. Saludcoop EPS. Universidad el Bosque. Bogotá, Colombia.

Camilo Manrique Martínez, MD.

Hospital Santa Clara. Universidad el Bosque. Bogotá, Colombia.

Francisco González Acosta, MD.

Hospital Santa Clara. Universidad el Bosque. Bogotá, Colombia.

Erika Paola Vergara Vela, MD.

Hospital Santa Clara. Bogotá, Colombia.

Mostrar biografía de los autores

Mauricio Moreno, MD.,

Medicina Interna Hospital Santa Clara. Bogotá, Colombia.

Oscar Sáenz Morales, MD.,

Internista Neumólogo. Coordinador servicio urgencias Hospital Santa Clara. Coordinador servicio medicina interna Saludcoop EPS, docente facultad de Medicina Universidad el Bosque. Bogotá, Colombia.

Camilo Manrique Martínez, MD.,

Medico Internista. Coordinador Servicio urgencias Hospital Santa Clara. Docente facultad de Medicina Universidad el Bosque. Bogotá, Colombia.

Francisco González Acosta, MD.,

Farmacólogo. Bioeticista. Servicio urgencias Hospital Santa Clara. Docente facultad de Medicina Universidad el Bosque. Bogotá, Colombia.

Erika Paola Vergara Vela, MD.,

Medico Internista. Servicio urgencias Hospital Santa Clara. Bogotá, Colombia.

Alberto Mario Pereira Garzón, MD.,

Medico Internista. Servicio urgencias Hospital Santa Clara. Bogotá, Colombia.

Rafael Miranda Jiménez, MD.,

Medico Epidemiólogo. Servicio de urgencias Hospital Santa Clara. Bogotá, Colombia.

macrólidos

efectos inmunomodulatorios

célula epitelial

enfermedad inflamatoria de la vía aérea

mediadores inflamatorios

Revisamos la actividad de los macrólidos en la enfermedad inflamatoria crónica de la vía aérea, haciendo énfasis en los efectos inmunomoduladores y antiinflamatorios sobre la célula epitelial. Describimos en detalle los mediadores humorales, celulares y las diferentes interacciones entre estos antibióticos y los mediadores inflamatorios circulantes, incluyendo procesos de apoptosis y oxidación, así como efectos sobre la defensa del epitelio, acciones sobre el moco, movimiento de iones, defensinas, depuración mucociliar y finalmente estabilización epitelial. Debido a estos mecanismos descritos, los macrólidos se convierten en una alternativa coadyuvante en el manejo de las enfermedades pulmonares infecciosas e inflamatorias.

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